Description

Levomefolate Heptaglutamate is the biologically active, polyglutamated form of folate, specifically the (6S)-5-methyltetrahydrofolate heptaglutamate. This compound is of critical importance in advanced nutritional science and pharmaceutical development due to its role as the primary circulatory and intracellular storage form of folate, offering superior bioavailability and metabolic utility compared to simpler folate derivatives. It is essential for manufacturers in the dietary supplement, clinical nutrition, and advanced pharmaceutical sectors seeking to develop high-efficacy products targeting folate deficiency, homocysteine metabolism, and prenatal health.

Application

• High-Potency Dietary Supplements: As a premium, bioavailable folate source in prenatal vitamins, multivitamins, and specialized nutraceuticals for metabolic support.
• Pharmaceutical Intermediates: Used in the synthesis of advanced folate-based therapeutics and targeted drug delivery systems.
• Clinical and Medical Nutrition: A key ingredient in medical food formulations and parenteral nutrition solutions for patients with specific metabolic disorders or malabsorption issues.
• Biochemical Research: Serves as a critical standard and reagent in enzymology, metabolic pathway studies, and cellular biology research focusing on one-carbon metabolism.
• Food Fortification (Specialized): Potential application in the fortification of specific functional foods and beverages where superior folate stability and activity are required.

Basic Information

Product Name	Levomefolate Heptaglutamate
CAS No.	35305-68-1
Molecular Formula	C84H122N22O35
Molecular Weight	~1912.0 g/mol
Synonyms	(6S)-5-Methyltetrahydrofolate Heptaglutamate; (6S)-5-Methyl-5,6,7,8-tetrahydrofolic Acid Heptaglutamate; L-Methylfolate Heptaglutamate; Metafolin® Heptaglutamate (referencing the active form); 5-MTHF Heptaglutamate; (6S)-5-MTHF-Glu7; Levomefolic Acid Heptaglutamate; the active form of Vitamin B9
EINECS	Contact for details

Quality Control

Our Levomefolate Heptaglutamate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and potency, with specifications aligned with pharmaceutical and high-grade nutraceutical standards. A comprehensive Certificate of Analysis (COA) detailing assay (by HPLC), related substances, residual solvents, and microbiological parameters is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC/UV)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm
Microbiological Analysis	Meets standard limits for total aerobic count, yeast & mold

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.