Description

7-Chloro-1-Methyl-5-Phenyl-3-[(Trimethylsilyl)Oxy]-1H-1,4-Benzodiazepin-2(3H)-One is a key protected intermediate in the synthesis of complex pharmaceutical compounds. Its value lies in providing a reactive handle for further chemical elaboration while protecting sensitive functional groups, enabling the efficient production of high-value active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process engineers in the pharmaceutical and fine chemical industries, particularly those focused on central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel benzodiazepine derivatives and related bioactive molecules.
• API Development: Used in research-scale and process development for potential new chemical entities (NCEs) targeting neurological and psychiatric disorders.
• Process Chemistry: Serves as a protected synthon in route scouting and optimization for more efficient and scalable manufacturing processes.
• Academic & Contract Research: A valuable reagent for medicinal chemistry programs in universities, research institutes, and contract research organizations (CROs).
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	7-Chloro-1-Methyl-5-Phenyl-3-[(Trimethylsilyl)Oxy]-1H-1,4-Benzodiazepin-2(3H)-One
CAS No.	35147-95-6
Molecular Formula	C21H23ClN2O2Si
Molecular Weight	398.96 g/mol
Synonyms	3-(Trimethylsilyloxy)-7-chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one; 7-Chloro-1-methyl-5-phenyl-3-(trimethylsiloxy)-1H-1,4-benzodiazepin-2(3H)-one; 1H-1,4-Benzodiazepin-2(3H)-one, 7-chloro-1-methyl-5-phenyl-3-[(trimethylsilyl)oxy]-; TMS-protected benzodiazepine intermediate; 7-Chloro-1-methyl-5-phenyl-1,4-benzodiazepin-2-one 3-O-trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 7-Chloro-1-Methyl-5-Phenyl-3-[(Trimethylsilyl)Oxy]-1H-1,4-Benzodiazepin-2(3H)-One is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for research and pharmaceutical development. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Related Substances (HPLC)	Total impurities ≤3.0%
Any single unknown impurity	≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.