Description

(5R)-2,6-Dioxo-1,7-Dioxaspiro[4.4]Nonane-8β-Carboxylic Acid is a high-purity, chiral spirocyclic compound that serves as a critical advanced intermediate in complex organic synthesis. Its unique rigid spirocyclic structure and defined stereochemistry make it invaluable for constructing sophisticated molecular architectures with precise spatial orientation. This compound is primarily sought after by research institutions and pharmaceutical development companies for applications in medicinal chemistry, including the synthesis of novel active pharmaceutical ingredients (APIs) and complex natural product analogs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs) targeting complex diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs) due to its constrained spirocyclic scaffold.
• Asymmetric Synthesis: Employed as a chiral template or auxiliary in catalytic and stoichiometric asymmetric reactions to induce stereoselectivity.
• Natural Product Synthesis: Serves as a synthetic precursor for constructing complex natural products containing spirocyclic or fused lactone motifs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Advanced Material Science: Investigated as a monomer or precursor for creating specialty polymers with unique thermal or optical properties.

Basic Information

Product Name	(5R)-2,6-Dioxo-1,7-Dioxaspiro[4.4]Nonane-8β-Carboxylic Acid
CAS No.	35135-55-8
Molecular Formula	C9H10O6
Molecular Weight	214.17 g/mol
Synonyms	(5R)-8-Carboxy-1,7-dioxaspiro[4.4]nonane-2,6-dione; (5R)-8-Carboxy-2,6-dioxo-1,7-dioxaspiro[4.4]nonane; (R)-2,6-Dioxo-1,7-dioxaspiro[4.4]nonane-8-carboxylic acid; (5R)-Spiroglutaric Acid Derivative; (R)-Spiro[1,4-dioxane-2,6'-oxolane]-3',5'-dione-8'-carboxylic acid; 8β-Carboxy-(5R)-1,7-dioxaspiro[4.4]nonane-2,6-dione
EINECS	Contact for details

Quality Control

Our (5R)-2,6-Dioxo-1,7-Dioxaspiro[4.4]Nonane-8β-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.