Description

1,2-Dihydrobenzocyclobutene-1-Carboxylic Acid Methyl Ester is a high-value, strained bicyclic organic compound that serves as a critical synthetic intermediate. Its unique fused cyclobutane-benzene structure makes it a versatile building block for constructing complex molecular architectures in advanced research and development. This compound is primarily sought after by pharmaceutical R&D teams and specialty chemical manufacturers for applications in medicinal chemistry and materials science.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry: Used as a rigid scaffold or a conformational constraint in drug discovery programs to explore structure-activity relationships (SAR).
• Organic Synthesis Building Block: Employed in Diels-Alder reactions and other cycloadditions to construct polycyclic compounds and natural product analogs.
• Materials Science Research: Investigated as a monomer or precursor for developing polymers with unique thermal or optical properties due to its strained ring system.
• Agrochemical Development: Intermediate in the research and synthesis of new crop protection agents and herbicides.
• Academic & Industrial R&D: Serves as a valuable reagent for methodological studies in organic chemistry and catalysis.

Basic Information

Product Name	1,2-Dihydrobenzocyclobutene-1-Carboxylic Acid Methyl Ester
CAS No.	35095-07-9
Molecular Formula	C11H10O2
Molecular Weight	174.20 g/mol
Synonyms	Methyl 1,2-dihydrocyclobutabenzen-1-carboxylate; 1-Carbomethoxy-1,2-dihydrobenzocyclobutene; Benzocyclobutene-1-carboxylic acid, 1,2-dihydro-, methyl ester; Methyl benzocyclobutene-1-carboxylate; 1,2-Dihydro-1-benzocyclobutenecarboxylic acid methyl ester; BCB ester derivative
EINECS	Contact for details

Quality Control

Our 1,2-Dihydrobenzocyclobutene-1-Carboxylic Acid Methyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to minimize exposure to moisture and air. Store away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.