Description

Poly(Estradiol Phosphate) is a polymeric prodrug of estradiol, designed for controlled and sustained release of the active hormone. This compound is of significant value in advanced pharmaceutical formulations where prolonged therapeutic effect and improved pharmacokinetic profiles are required. It is primarily needed by pharmaceutical manufacturers and research institutions developing long-acting hormone replacement therapies and oncology treatments.

Application

• Long-acting Hormone Replacement Therapy (HRT): A key component in formulations for sustained-release estrogen therapy, particularly for postmenopausal symptoms.
• Oncology Research: Used in the development of targeted and controlled-release chemotherapeutic agents for hormone-sensitive cancers, such as prostate and breast cancer.
• Advanced Drug Delivery Systems: Serves as a biodegradable polymer carrier in implants, microspheres, and injectable depots for prolonged drug release.
• Pharmaceutical Intermediate: Acts as a critical synthetic intermediate for producing specialized estradiol-based prodrugs with enhanced stability and bioavailability.
• Biomedical Research: Utilized in preclinical and clinical studies to investigate the efficacy and safety of sustained estrogen delivery.
• Veterinary Pharmaceuticals: Applied in developing long-acting hormonal treatments for animals.

Basic Information

Product Name	Poly(Estradiol Phosphate)
CAS No.	34828-67-6
Molecular Formula	(C18H23O4P)n
Molecular Weight	Variable (Polymer)
Synonyms	Estradiol Phosphate Polymer; Polyestradiol Phosphate; Estradiol Polyphosphate; PEP; Estradurin (brand name); Estradiol 17-Phosphate Polymer; NSC-112259; Polymeric Estradiol Phosphate
EINECS	Contact for details

Quality Control

Our Poly(Estradiol Phosphate) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing key parameters such as polymer molecular weight distribution, estradiol content, residual solvents, and related substances are provided to support your regulatory and formulation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to reference spectrum
Assay (Estradiol Content)	Contact for details
Molecular Weight (Average)	Contact for details
Loss on Drying	≤ 2.0%
Residual Solvents	Complies with ICH guidelines
Related Substances (HPLC)	Contact for details
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.