Description

6-Chloro-1-Trimethylsilyloxyhexane is a versatile organosilicon reagent featuring a protected terminal hydroxyl group and a reactive chloroalkyl chain. This compound is a critical building block in organic synthesis, valued for its ability to introduce functionalized hexyl moieties under mild conditions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in the synthesis of compounds with extended alkyl linkers.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators requiring specific hydrophobic side chains.
• Polymer & Material Science: Serves as a functional monomer or cross-linking agent for modifying silicone polymers and creating specialty coatings with tailored properties.
• Organic Synthesis Reagent: Employed in nucleophilic substitution reactions, Grignard reagent formation, and as a precursor for further functional group transformations (e.g., conversion to azides, amines, or other nucleophiles).
• Liquid Crystal & OLED Material Precursor: A valuable starting material for synthesizing alkylated components used in display and lighting technologies.
• Protecting Group Strategy: The trimethylsilyloxy (OTMS) group protects the alcohol functionality during multi-step syntheses, which can be selectively deprotected later.

Basic Information

Product Name	6-Chloro-1-Trimethylsilyloxyhexane
CAS No.	34714-00-6
Molecular Formula	C9H21ClOSi
Molecular Weight	208.80 g/mol
Synonyms	1-Chloro-6-(trimethylsilyloxy)hexane; 6-Chlorohexyloxytrimethylsilane; Hexane, 1-chloro-6-(trimethylsilyloxy)-; (6-Chlorohexyloxy)trimethylsilane; Trimethyl(6-chlorohexyloxy)silane; O-Trimethylsilyl-6-chloro-1-hexanol; 6-Chlorohexanol trimethylsilyl ether; TMS-Protected 6-Chloro-1-hexanol
EINECS	Contact for details

Quality Control

Our 6-Chloro-1-Trimethylsilyloxyhexane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.