Description

(-)-Di[(1R)-Menthyl] Fumarate is a high-purity, chiral auxiliary and resolving agent derived from natural (1R)-menthol. This compound is critically important in asymmetric synthesis and chiral separations, enabling the production of enantiomerically pure intermediates for advanced pharmaceuticals and fine chemicals. It is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to control stereochemistry with high efficiency.

Application

• Chiral Resolution Agent: For the separation of racemic mixtures of acids, amines, and other chiral compounds.
• Asymmetric Synthesis Auxiliary: Used to induce chirality in synthetic pathways for pharmaceutical active ingredients (APIs).
• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of stereochemically defined drug candidates.
• Catalyst Ligand Precursor: Employed in the development of chiral catalysts for enantioselective reactions.
• Analytical Standard: Used as a reference standard in HPLC and chiral chromatography for method development and quality control.
• Fine Chemical Synthesis: Applied in the production of high-value specialty chemicals where optical purity is paramount.

Basic Information

Product Name	(-)-Di[(1R)-Menthyl] Fumarate
CAS No.	34675-24-6
Molecular Formula	C₂₄H₄₀O₄
Molecular Weight	392.57 g/mol
Synonyms	(-)-Di-(1R-Menthyl) Fumarate; (R,R)-Di-menthyl Fumarate; Fumaric Acid Di-[(1R)-menthyl] Ester; L-Menthyl Fumarate; Bis[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl] (E)-but-2-enedioate; Di-O-menthyl Fumarate; (1R,1'R)-2,2'-Dimethyl-3,3'-(1,2-ethenediyl)bis[1-(1-methylethyl)-4-methylcyclohexane]carboxylate
EINECS	Contact for details

Quality Control

Our (-)-Di[(1R)-Menthyl] Fumarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, and specific rotation is provided with every shipment to guarantee reliable performance and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]₂₀D	-80° to -85° (c=1 in CHCl₃)
Melting Point	78°C - 82°C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.