Description

2-O,5-o-Bis(trimethylsilyl)-2-C-[[(trimethylsilyl)oxy]methyl]-3-deoxy-D-erythro-pentonic acid γ-lactone is a sophisticated organosilicon-protected carbohydrate derivative, specifically a silylated lactone. This compound serves as a critical chiral building block and protective intermediate in advanced organic synthesis, enabling precise control over stereochemistry and functional group manipulation. It is primarily required by pharmaceutical R&D and fine chemical manufacturers for the synthesis of nucleoside analogs, antiviral agents, and other complex bioactive molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of modified nucleosides and nucleotide analogs with potential antiviral or anticancer activity.
• Chiral Building Block: Utilized in asymmetric synthesis to construct complex natural products and active pharmaceutical ingredients (APIs) with defined stereocenters.
• Carbohydrate Chemistry: Serves as a protected sugar derivative for the preparation of glycosylation donors, acceptors, and other complex oligosaccharide mimetics.
• Fine Chemical Synthesis: Intermediate for producing specialty chemicals, agrochemicals, and advanced materials requiring specific stereochemical configurations.
• Research & Development: Used in academic and industrial labs for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Item	Detail
Product Name	2-O,5-o-Bis(trimethylsilyl)-2-C-[[(trimethylsilyl)oxy]methyl]-3-deoxy-D-erythro-pentonic acid γ-lactone
CAS No.	34641-57-1
Molecular Formula	C17H38O5Si3
Molecular Weight	406.73 g/mol
Synonyms	3-Deoxy-2-C-[(trimethylsilyloxy)methyl]-2,5-O-bis(trimethylsilyl)-D-erythro-pentonic acid γ-lactone; 2,5-O-Bis(trimethylsilyl)-2-C-[(trimethylsilyloxy)methyl]-3-deoxy-D-erythro-pentono-1,4-lactone; Silylated 3-deoxy-D-erythro-pentonic acid lactone; TMS-protected pentonic acid lactone; 34641-57-1; (3R,4R)-4-[(Trimethylsilyloxy)methyl]-3-[(trimethylsilyloxy]-5-[(trimethylsilyloxy]dihydrofuran-2(3H)-one
EINECS	Contact for details

Quality Control

Our 2-O,5-o-Bis(trimethylsilyl)-2-C-[[(trimethylsilyl)oxy]methyl]-3-deoxy-D-erythro-pentonic acid γ-lactone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and stereochemical integrity. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its highly volatile nature and sensitivity to moisture, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.