Description

6α-Naloxol Hydrochloride is a high-purity pharmaceutical intermediate and reference standard of significant importance in medicinal chemistry and analytical research. This compound is a key precursor in the synthesis of naloxone and related opioid antagonists, which are critical for addressing opioid overdoses and dependency. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and analytical service providers engaged in the development and quality control of life-saving opioid antagonist therapies.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of naloxone and naltrexone, essential opioid receptor antagonists.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC/QA) testing of active pharmaceutical ingredients (APIs) and finished dosage forms.
• Medicinal Chemistry Research: Serves as a core structure for designing and synthesizing novel opioid receptor ligands to study receptor interactions and develop new therapeutic agents.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research related to naloxone and its analogs.
• Impurity Standard: Used to identify, quantify, and control potential process-related impurities in naloxone API manufacturing.

Basic Information

Product Name	6α-Naloxol Hydrochloride
CAS No.	34520-00-8
Molecular Formula	C19H22ClNO4
Molecular Weight	363.84 g/mol
Synonyms	6α-Naloxol HCl; 17-Allyl-4,5α-epoxy-3,14-dihydroxymorphinan-6α-ol hydrochloride; Naloxol hydrochloride; 6α-Naloxol hydrochloride salt; Noroxymorphone derivative; 6α-Hydroxy-naltrexol hydrochloride (related); Opioid antagonist intermediate
EINECS	Contact for details

Quality Control

Our 6α-Naloxol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.