Description

tert-Butyl 2-Isocyanopropionate is a versatile isocyanate ester building block used in organic synthesis. This compound is particularly valuable for introducing the tert-butyloxycarbonyl (Boc) protected amine functionality via its reactive isocyanate group. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require high-purity intermediates for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring Boc-protected amino acid derivatives.
• Peptide Synthesis: Used in the preparation of peptide analogs and mimetics where the isocyanate group facilitates specific coupling reactions.
• Agrochemical Synthesis: Intermediate in the production of advanced herbicides, fungicides, and insecticides that incorporate carbamate or urea functionalities.
• Polymer Chemistry: Serves as a monomer or chain extender in the synthesis of specialized polyurethanes and polyureas with tailored properties.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel chemical entities.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule development and scale-up projects.

Basic Information

Product Name	tert-Butyl 2-Isocyanopropionate
CAS No.	34074-64-1
Molecular Formula	C8H13NO3
Molecular Weight	171.19 g/mol
Synonyms	2-Isocyanopropionic Acid tert-Butyl Ester; Propanoic Acid, 2-Isocyanato-, 1,1-Dimethylethyl Ester; tert-Butyl 2-Isocyanatopropanoate; 1,1-Dimethylethyl 2-Isocyanatopropanoate; Boc-Protected Alanine Isocyanate; Alanine NCA tert-Butyl Ester (derivative); (2-Isocyanatopropanoyl)oxy-tert-butane
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Isocyanopropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.