Description

Cholesteryl 2-Propyn-1-Yl Carbonate is a functionalized cholesterol derivative where the 3β-hydroxyl group is modified with a propargyl carbonate moiety. This compound is a valuable synthetic intermediate, prized for its unique chemical handle that enables further modification via click chemistry reactions such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily sought after by researchers and manufacturers in the life sciences sector for the development of advanced materials, drug delivery systems, and bioactive probes.

Application

• Pharmaceutical Research & Development: As a key building block for synthesizing novel cholesterol-conjugated prodrugs, targeted therapeutics, and imaging agents.
• Bioconjugation & Click Chemistry: Enables site-specific labeling and functionalization of biomolecules (proteins, lipids, nucleic acids) through its reactive alkyne group.
• Lipid Nanoparticle (LNP) Formulation: Used in the design and synthesis of novel ionizable or helper lipids to optimize the stability and delivery efficiency of mRNA and siRNA therapeutics.
• Polymer & Material Science: Serves as a monomer or cross-linker for creating functional polymers, hydrogels, and biomimetic materials with cholesterol-based properties.
• Diagnostic Reagents: Employed in the development of cholesterol-based sensors, assay components, and diagnostic kits.
• Academic & Industrial Research: A critical tool for studying lipid metabolism, membrane biophysics, and cellular signaling pathways.

Basic Information

Product Name	Cholesteryl 2-Propyn-1-Yl Carbonate
CAS No.	33985-07-8
Molecular Formula	C31H48O3
Molecular Weight	468.71 g/mol
Synonyms	Cholesteryl propargyl carbonate; 3β-Cholest-5-en-3-yl 2-propyn-1-yl carbonate; 5-Cholesten-3β-ol 3-(2-propynyl) carbonate; Cholesterol propargyl carbonate; Propargyl cholesteryl carbonate; 2-Propyn-1-yl cholesteryl carbonate; (3β)-Cholest-5-en-3-yl prop-2-yn-1-yl carbonate
EINECS	Contact for details

Quality Control

Our Cholesteryl 2-Propyn-1-Yl Carbonate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The compound is sensitive to strong acids and organic solvents; keep away from incompatible materials. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.