Description

Chlorambucil n-Oxide is a nitrogen mustard derivative and an oxidative metabolite of the alkylating agent chlorambucil. This compound is of significant interest in pharmaceutical research and development, particularly in the study of drug metabolism and the design of novel prodrugs. It serves as a critical reference standard and intermediate for researchers and manufacturers in the oncology and medicinal chemistry sectors, enabling the advancement of targeted cancer therapies.

Application

• Pharmaceutical Reference Standard: Used for analytical method development, validation, and quality control in drug testing laboratories.
• Metabolite Research: Essential for studying the metabolic pathways, pharmacokinetics, and bioactivation mechanisms of chlorambucil.
• Medicinal Chemistry Intermediate: Serves as a key building block in the synthesis of novel alkylating agents and targeted cancer therapeutics.
• Oncology R&D: Employed in preclinical research to investigate the efficacy and toxicity profiles of chlorambucil derivatives.
• Biochemical Research: Used in studies exploring DNA alkylation and mechanisms of action of chemotherapeutic agents.
• Impurity Standard: Critical for identifying and quantifying process-related impurities in chlorambucil API manufacturing.

Basic Information

Product Name	Chlorambucil n-Oxide
CAS No.	33845-63-5
Molecular Formula	C14H19Cl2NO3
Molecular Weight	320.21 g/mol
Synonyms	4-[Bis(2-chloroethyl)amino]benzenebutanoic Acid N-Oxide; Chlorambucil Oxide; NSC 33845; Chlorambucil N-Oxide; Leukeran N-Oxide; p-[N,N-Bis(2-chloroethyl)amino]phenylbutyric Acid N-Oxide; CB-1348 N-Oxide
EINECS	Contact for details

Quality Control

Our Chlorambucil n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR), to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.