Description

1-O,2-O,3-O,4-O,5-o-Pentakis(Trimethylsilyl)-D-Mannitol 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a fully silylated derivative of D-mannitol, featuring a protected phosphate group, designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise control over reactivity and solubility in complex organic synthesis. It serves as a key protected intermediate and building block for the development of pharmaceuticals, specialty carbohydrates, and sophisticated organosilicon materials.

Application

• Pharmaceutical Intermediate: Used in the synthesis of complex carbohydrate-based drugs, nucleoside analogs, and prodrugs where phosphate protection is required.
• Carbohydrate Chemistry: Acts as a pivotal building block for the preparation of selectively protected mannitol derivatives and other sugar analogs for research and development.
• Organosilicon Reagent: Serves as a valuable reagent in silicon-mediated transformations, leveraging the trimethylsilyl groups for temporary protection and subsequent functionalization.
• Chemical Derivatization: Employed in gas chromatography (GC) and mass spectrometry (MS) as a derivatization agent to enhance the volatility and detectability of polar compounds like polyols and phosphates.
• Material Science Precursor: Utilized in the development of novel silicon-containing polymers and hybrid organic-inorganic materials with tailored properties.
• Bioconjugation & Labeling: Facilitates the introduction of protected phosphate functionalities into biomolecules for targeted drug delivery systems and diagnostic probes.

Basic Information

Product Name	1-O,2-O,3-O,4-O,5-o-Pentakis(Trimethylsilyl)-D-Mannitol 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	33800-37-2
Molecular Formula	C27H69O9PSi7
Molecular Weight	777.41 g/mol
Synonyms	D-Mannitol, 1,2,3,4,5-pentakis-O-(trimethylsilyl)-, 6-(bis(trimethylsilyl) phosphate); Hexakis(trimethylsilyl) D-Mannitol Phosphate Ester; Per(trimethylsilyl) Mannitol Phosphate; D-Mannitol, pentakis(trimethylsilyl) ether, 6-(phosphoric acid bis(trimethylsilyl) ester); TMS-Mannitol Phosphate Ester; Fully Silylated D-Mannitol 6-Phosphate
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-O,5-o-Pentakis(Trimethylsilyl)-D-Mannitol 6-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture ingress and decomposition. Handle and store under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.