Description

17β-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-3-Ol 3-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is a key silylated derivative of estradiol, designed to enhance stability and reactivity for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise, protected intermediates in complex organic synthesis. It is primarily utilized in the development of novel steroid-based pharmaceuticals, high-purity reference standards, and specialized chemical probes.

Application

• Pharmaceutical Intermediate: A crucial protected intermediate in the multi-step synthesis of novel steroidal drugs and hormone analogs.
• Reference Standard: Used as a high-purity analytical standard in quality control and method development for steroid analysis.
• Chemical Research: Serves as a key reagent in academic and industrial research exploring new steroid derivatives and their biological activities.
• Prodrug Development: Utilized in the design and synthesis of prodrug candidates where silyl groups act as protective moieties for controlled release.
• Bioconjugation: Acts as a building block for creating steroid-protein or steroid-peptide conjugates for diagnostic and therapeutic applications.

Basic Information

Product Name	17β-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-3-Ol 3-[Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	33745-64-1
Molecular Formula	C27H47O5PSi3
Molecular Weight	554.88 g/mol
Synonyms	Estradiol 3,17-bis(trimethylsilyl) ether phosphate; 3,17β-Bis(trimethylsilyloxy)estra-1,3,5(10)-trien-3-yl dihydrogen phosphate (silylated); Estradiol 3-phosphate bis(trimethylsilyl) ester; Silylated Estradiol Phosphate Ester; 17β-(TMS-Oxy)estra-1,3,5(10)-trien-3-ol 3-[phosphoric acid bis(TMS)] ester; NSC 163063; Estrone 3-phosphate TMS derivative (related compound)
EINECS	Contact for details

Quality Control

Every batch of 17β-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-3-Ol 3-[Phosphoric Acid Bis(Trimethylsilyl)] Ester is manufactured and tested under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity suitable for research and development. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.