Description

3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17β-Ol [Phosphoric Acid Bis(Trimethylsilyl)] Ester is a high-purity, organosilicon-protected steroid derivative, specifically designed for advanced synthetic chemistry and pharmaceutical research. This compound is a critical synthetic intermediate, offering enhanced stability and reactivity for the controlled modification of steroidal frameworks. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors for the synthesis of novel therapeutic agents and reference standards.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of novel steroid-based drugs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial R&D for exploring new steroidal structures with potential biological activity.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of complex steroid molecules.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Derivatization Agent: The trimethylsilyl (TMS) protecting groups facilitate specific reactions and improve compound handling during synthesis.

Basic Information

Product Name	3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17β-Ol [Phosphoric Acid Bis(Trimethylsilyl)] Ester
CAS No.	33745-63-0
Molecular Formula	C26H47O5PSi3
Molecular Weight	530.87 g/mol
Synonyms	17β-Estradiol 3-(trimethylsilyl) ether bis(trimethylsilyl) phosphate; Estra-1,3,5(10)-triene-3,17-diol, 3-(trimethylsilyl) ether, 17-(dihydrogen phosphate), bis(trimethylsilyl) ester; 17β-Estradiol 3-TMS ether bis-TMS phosphate; Phosphoric Acid, Bis(trimethylsilyl) Ester, Ester with 3-(Trimethylsilyloxy)estra-1,3,5(10)-trien-17β-ol; TMS-Estradiol Phosphate (TMS)2; 33745-63-0
EINECS	Contact for details

Quality Control

Our production of 3-(Trimethylsilyloxy)Estra-1,3,5(10)-Trien-17β-Ol [Phosphoric Acid Bis(Trimethylsilyl)] Ester adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing results from HPLC, NMR, and other relevant tests are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.