Description

Estrone Phosphoric Acid Bis(Trimethylsilyl) Ester CAS NO 33745-62-9 is a key protected derivative of the natural estrogen, estrone, designed for advanced synthetic and analytical chemistry. This compound is critical for researchers and manufacturers requiring precise, stable intermediates in complex organic synthesis. It is primarily utilized in pharmaceutical R&D, analytical reference standard preparation, and the synthesis of novel steroid-based compounds.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of steroidal drugs and hormone analogs.
• Analytical Reference Standard: Used for method development, calibration, and quality control in HPLC, GC-MS, and LC-MS analysis of estrogenic compounds.
• Protecting Group Chemistry: The bis(trimethylsilyl) phosphate group protects reactive hydroxyl and phosphate functionalities during sensitive synthetic transformations.
• Biochemical Research: Employed in metabolic studies, receptor binding assays, and the development of labeled tracers for estrogen pathway research.
• Process Chemistry Development: Serves as a high-purity intermediate for scaling up the production of specialized steroid derivatives under controlled conditions.

Basic Information

Product Name	Estrone Phosphoric Acid Bis(Trimethylsilyl) Ester
CAS No.	33745-62-9
Molecular Formula	C27H45O5PSi2
Molecular Weight	536.87 g/mol
Synonyms	Estrone 3-(Bis(trimethylsilyl)phosphate); Estrone Phosphoric Acid Bis(TMS) Ester; 3-Hydroxyestra-1,3,5(10)-trien-17-one 3-(Bis(trimethylsilyl)phosphate); Estrone Bis(trimethylsilyl) Phosphate; O-Phosphonoestrone Bis(trimethylsilyl) Ester; E1 Phosphoric Acid Bis(TMS) Ester
EINECS	Contact for details

Quality Control

Our Estrone Phosphoric Acid Bis(Trimethylsilyl) Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with rigorous research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.