Description

2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose is a key protected ribose derivative, extensively utilized as a sophisticated building block in organic synthesis. Its value lies in providing a fully silylated, moisture-sensitive intermediate that enables precise, multi-step reactions under anhydrous conditions. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of nucleoside analogs, complex carbohydrates, and other high-value specialty chemicals.

Application

• Nucleoside and Nucleotide Synthesis: A critical protected intermediate for constructing modified ribose backbones in antiviral and anticancer drug candidates.
• Carbohydrate Chemistry: Used in the selective synthesis of complex oligosaccharides and glycoconjugates where precise protection/deprotection strategies are required.
• Pharmaceutical Intermediates: Serves as a high-purity starting material for active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Fine Chemical Production: Employed in research-scale and pilot-scale synthesis of specialty chemicals requiring controlled manipulation of hydroxyl groups.
• Process Chemistry Development: Valued for its stability under anhydrous conditions, facilitating scalable manufacturing processes for sensitive molecules.
• Bioconjugation and Probe Development: Useful in creating labeled sugars or sugar derivatives for biochemical research and diagnostic applications.

Basic Information

Product Name	2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose
CAS No.	33648-69-0
Molecular Formula	C17H42O5Si4
Molecular Weight	438.86 g/mol
Synonyms	D-Ribose, 2,3,4,5-tetrakis-O-(trimethylsilyl)-; Tetrakis-O-trimethylsilyl-D-ribose; 2,3,4,5-Tetra-O-trimethylsilyl-D-ribofuranose; Per-O-trimethylsilyl-D-ribose; TMS-D-Ribose (fully protected); D-Ribose tetrakis(trimethylsilyl) ether; 33648-69-0; Fully silylated D-ribose
EINECS	Contact for details

Quality Control

Our 2-O,3-O,4-O,5-o-Tetrakis(Trimethylsilyl)-D-Ribose is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 90.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.