Description

2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Arabino-Hexonic Acid γ-Lactone is a high-purity, protected sugar lactone derivative, serving as a critical chiral building block and advanced synthetic intermediate. Its value lies in enabling precise, multi-step organic synthesis, particularly in the construction of complex bioactive molecules where stereochemical control is paramount. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries, facilitating the production of novel APIs, nucleoside analogs, and specialty carbohydrates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of nucleoside analogs, antiviral agents, and other complex active pharmaceutical ingredients (APIs).
• Carbohydrate Chemistry: Used in the selective protection and functionalization of sugar molecules for the development of glycoconjugates and glycomimetics.
• Agrochemical Research: Serves as a building block for creating novel, stereochemically-defined active ingredients with specific biological activity.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for constructing complex natural product analogs and specialty chemicals.
• Process Development: Utilized in route scouting and optimization for scalable manufacturing of high-value chiral compounds.
• Academic & R&D: A valuable reagent for methodological studies in asymmetric synthesis and medicinal chemistry research programs.

Basic Information

Product Name	2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Arabino-Hexonic Acid γ-Lactone
CAS No.	33648-66-7
Molecular Formula	C18H40O6Si3
Molecular Weight	460.78 g/mol
Synonyms	3-Deoxy-D-arabino-hexonic acid γ-lactone, 2,5,6-tris-O-(trimethylsilyl)-; 2,5,6-Tri-O-trimethylsilyl-3-deoxy-D-arabino-hexono-1,4-lactone; Tris(trimethylsilyl) protected 3-deoxyhexonolactone; TMS-protected sugar lactone; 3-Deoxy-D-arabino-hexono-1,4-lactone 2,5,6-tris(trimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our 2-O,5-O,6-o-Tris(Trimethylsilyl)-3-Deoxy-D-Arabino-Hexonic Acid γ-Lactone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.