Description

3,5-Bis(Trifluoromethyl)Phenyldimethylsilane is a high-value organosilicon intermediate featuring a phenyl ring substituted with two trifluoromethyl groups. This compound matters for its unique combination of silicon-based reactivity and the lipophilicity and electron-withdrawing properties imparted by the trifluoromethyl substituents, making it a critical building block in advanced synthesis. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the lipophilic 3,5-bis(trifluoromethyl)phenyl moiety to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorinated aromatic group enhances product efficacy and environmental persistence.
• Ligand & Catalyst Development: Serves as a foundational unit for constructing sophisticated ligands in asymmetric catalysis and organometallic complexes.
• Material Science: Employed in the development of specialty polymers, liquid crystals, and advanced coatings to impart specific thermal, chemical, or surface properties.
• Organic Electronics: Potential building block for electron-transport materials or modifiers in OLEDs and other electronic devices due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The silicon group can be utilized in Hiyama-type cross-coupling reactions as an alternative to boron or tin reagents.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Phenyldimethylsilane
CAS No.	33558-36-0
Molecular Formula	C10H10F6Si
Molecular Weight	272.26 g/mol
Synonyms	Dimethyl[3,5-bis(trifluoromethyl)phenyl]silane; [3,5-Bis(trifluoromethyl)phenyl]dimethylsilane; Silane, dimethyl[3,5-bis(trifluoromethyl)phenyl]-; 3,5-Bis(trifluoromethyl)benzyldimethylsilane (common misnomer); α,α-Bis(trifluoromethyl)benzyldimethylsilane; (3,5-Bis(trifluoromethyl)phenyl)dimethylsilane
EINECS	Contact for details

Quality Control

Our production of 3,5-Bis(Trifluoromethyl)Phenyldimethylsilane adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including GC, NMR, and HPLC analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support cGMP and ISO 9001 standards for quality management.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis and maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.