Description

Dimethyl (R)-2-Methylglutarate is a high-purity chiral building block and specialty ester of significant value in advanced organic synthesis. Its enantiomerically pure (R)-configuration makes it a critical intermediate for the production of optically active pharmaceuticals and fine chemicals. This compound is essential for research and manufacturing chemists in the pharmaceutical, agrochemical, and fragrance industries who require a reliable source of a specific stereoisomer for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in routes requiring the (R)-2-methylglutaric acid backbone.
• Asymmetric Synthesis: Serves as a starting material or precursor in catalytic asymmetric reactions to introduce stereocenters.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, including advanced polymers, liquid crystals, and performance materials.
• Agrochemical Synthesis: Intermediate in the production of chiral herbicides, fungicides, and plant growth regulators.
• Flavor and Fragrance Industry: Potential precursor for the synthesis of ester-based aroma compounds.
• Academic and R&D: Valuable reagent for methodological development in organic chemistry and medicinal chemistry research.

Basic Information

Product Name	Dimethyl (R)-2-Methylglutarate
CAS No.	33514-22-6
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	(R)-2-Methylpentanedioic Acid Dimethyl Ester; Dimethyl (2R)-2-Methylpentanedioate; (R)-(-)-2-Methylglutaric Acid Dimethyl Ester; Methyl (R)-2-Methylglutarate; (R)-2-Methylglutaric Acid Dimethyl Ester; (R)-Dimethyl 2-Methylglutarate; (2R)-2-Methylpentanedioic Acid Dimethyl Ester
EINECS	Contact for details

Quality Control

Our Dimethyl (R)-2-Methylglutarate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profile is provided with every shipment to guarantee consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.