Description

(R)-(+)-1-Phenylethyl Isocyanate CAS NO 33375-06-3 is a high-purity, chiral isocyanate derivative characterized by its reactive N=C=O functional group and a stereogenic center. This compound matters as a versatile and critical chiral building block for the synthesis of optically active ureas, carbamates, and other pharmacologically relevant molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating enantiomerically pure active ingredients, as well as by fine chemical manufacturers producing advanced intermediates for asymmetric synthesis.

Application

• Chiral Auxiliary and Resolving Agent: Used for the resolution of racemic mixtures of alcohols and amines via diastereomeric carbamate formation.
• Pharmaceutical Intermediate: A key synthon in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly those containing chiral amine or alcohol motifs.
• Agrochemical Synthesis: Employed in the production of chiral pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing chiral ligands used in asymmetric catalysis, such as in hydrogenation or alkylation reactions.
• Polymer Modification: Used to introduce chiral phenyl ethyl groups into polymers, potentially altering material properties for specialized applications.
• Protecting Group Chemistry: The isocyanate group can be used to temporarily protect amines, with the chiral center allowing for subsequent stereoselective transformations.

Basic Information

Product Name	(R)-(+)-1-Phenylethyl Isocyanate
CAS No.	33375-06-3
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
Synonyms	(R)-(+)-α-Methylbenzyl isocyanate; (R)-1-Phenylethyl isocyanate; (R)-PEIC; (+)-(R)-1-Phenylethyl isocyanate; (R)-1-Phenethyl isocyanate; (R)-(-)-1-Phenylethyl isocyanate (Note: Verify specific rotation); (R)-Methylphenylcarbinyl isocyanate; Isocyanic acid, (1R)-1-phenylethyl ester
EINECS	Contact for details

Quality Control

Our (R)-(+)-1-Phenylethyl Isocyanate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC or GC, to ensure high enantiomeric excess (ee) and chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications for assay, optical rotation, identity, and impurity profiles. Our quality systems support compliance with cGMP and ISO standards for reliable, batch-to-batch consistency demanded by advanced synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, alcohols, and amines. Keep the container tightly sealed under a dry inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and polymerization. Isolate from heat, sparks, open flames, and incompatible materials such as strong bases, acids, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC/GC)	≥ 99.0% ee
Specific Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.