Description

2'-[(Trimethylsilyl)Oxy]Valerophenone is a specialized organosilicon-protected ketone derivative, serving as a critical synthetic intermediate in advanced organic synthesis. Its primary value lies in the trimethylsilyl (TMS) protecting group, which offers enhanced stability and controlled reactivity for sensitive functional group transformations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for developing active pharmaceutical ingredients (APIs) and complex organic molecules.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Advanced Organic Synthesis: Used as a protected precursor in Grignard reactions, nucleophilic additions, and other carbonyl chemistry where temporary protection of the hydroxyl group is required.
• Agrochemical Research: Intermediate in the development of novel pesticides, herbicides, and plant growth regulators.
• Material Science Precursor: Serves as a starting material for synthesizing specialized silicon-containing polymers or advanced organic materials.
• Academic & R&D Laboratories: Valuable reagent for methodological development and exploring new synthetic pathways in university and industrial research settings.

Basic Information

Product Name	2'-[(Trimethylsilyl)Oxy]Valerophenone
CAS No.	33342-91-5
Molecular Formula	C14H22O2Si
Molecular Weight	250.41 g/mol
Synonyms	Valerophenone, 2'-[(trimethylsilyl)oxy]-; 1-[2-(Trimethylsilyloxy)phenyl]-1-pentanone; 2-(Trimethylsiloxy)valerophenone; O-Trimethylsilylvalerophenone; 2'-Hydroxyvalerophenone trimethylsilyl ether; 2'-Valerophenone TMS ether; TMS-Valerophenone; CAS 33342-91-5
EINECS	Contact for details

Quality Control

Our 2'-[(Trimethylsilyl)Oxy]Valerophenone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and industrial use. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.