Description

3'-(Trimethylsilyloxy)Acetophenone is a specialized organosilicon compound featuring a trimethylsilyl-protected phenolic hydroxyl group. This chemical serves as a valuable protected intermediate and synthetic building block in advanced organic synthesis, enabling precise chemical transformations. It is primarily utilized by research and development chemists and process engineers in the pharmaceutical and fine chemical industries for the production of complex molecules.

Application

• Pharmaceutical Intermediate: A key protected synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly those containing phenolic or ketone functionalities.
• Organic Synthesis Building Block: Used in reactions such as Friedel-Crafts acylation, Grignard reactions, and nucleophilic substitutions where a protected phenol is required.
• Agrochemical Research: Employed in the development and synthesis of novel pesticide and herbicide candidates.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of specialized polymers and advanced organic materials.
• Academic & Industrial R&D: Serves as a versatile reagent in method development and exploratory chemistry within university and corporate research laboratories.

Basic Information

Product Name	3'-(Trimethylsilyloxy)Acetophenone
CAS No.	33342-86-8
Molecular Formula	C11H16O2Si
Molecular Weight	208.33 g/mol
Synonyms	1-[3-(Trimethylsilyloxy)phenyl]ethanone; 3-Acetylphenyl trimethylsilyl ether; m-(Trimethylsilyloxy)acetophenone; 3'-Hydroxyacetophenone trimethylsilyl ether; TMS-protected 3'-Hydroxyacetophenone; 3-Acetophenone trimethylsilyl ether; 3-(Trimethylsiloxy)acetophenone
EINECS	Contact for details

Quality Control

Our production of 3'-(Trimethylsilyloxy)Acetophenone adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability. Each lot is characterized using advanced analytical techniques including GC, HPLC, and NMR to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.