Description

2'-[(Trimethylsilyl)Oxy]Acetophenone is a specialized organosilicon-protected derivative of acetophenone, serving as a versatile synthetic intermediate in advanced organic chemistry. Its core value lies in the trimethylsilyl (TMS) protecting group, which offers enhanced stability and reactivity control for sensitive functional group manipulations. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of complex molecules where precise protection and deprotection strategies are required.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing phenolic or ketone functionalities.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where the protected hydroxyl group is a critical structural element.
• Fine Chemical Production: Serves as a precursor for fragrances, flavors, and other specialty chemicals requiring controlled oxidation or substitution reactions.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis, including studies on silyl ether protection/deprotection kinetics.
• Material Science Precursor: Potential intermediate in the synthesis of organic ligands or monomers for advanced polymeric materials.

Basic Information

Product Name	2'-[(Trimethylsilyl)Oxy]Acetophenone
CAS No.	33342-85-7
Molecular Formula	C₁₁H₁₆O₂Si
Molecular Weight	208.33 g/mol
Synonyms	1-[2-(Trimethylsilyloxy)phenyl]ethanone; 2-Acetylphenyl trimethylsilyl ether; o-(Trimethylsilyloxy)acetophenone; 2-(Trimethylsiloxy)acetophenone; TMS-protected 2-hydroxyacetophenone; CAS 33342-85-7; 2'-TMSO Acetophenone
EINECS	Contact for details

Quality Control

Our 2'-[(Trimethylsilyl)Oxy]Acetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.