Description

3β,16α,17β-Tris(Trimethylsilyloxy)Androst-5-Ene is a high-purity, multi-functional steroid derivative, specifically designed as a key protected intermediate for advanced organic synthesis. Its value lies in providing a stable, silyl-protected scaffold that enables precise and selective downstream chemical modifications. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the development of novel steroid-based therapeutics and high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Research & Development: Used in academic and industrial R&D laboratories for exploring new synthetic pathways and creating novel steroid derivatives with potential biological activity.
• Fine Chemical Synthesis: Serves as a protected precursor for manufacturing high-value specialty chemicals used in various advanced material and life science applications.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial production of steroid compounds, where its protected hydroxyl groups offer strategic advantages.

Basic Information

Product Name	3β,16α,17β-Tris(Trimethylsilyloxy)Androst-5-Ene
CAS No.	33287-32-0
Molecular Formula	C27H52O3Si3
Molecular Weight	509.0 g/mol
Synonyms	Androst-5-ene-3β,16α,17β-triol, tris(trimethylsilyl) ether; 3β,16α,17β-Tris-O-(trimethylsilyl)androst-5-ene; Tris(trimethylsilyl) androst-5-ene-3β,16α,17β-triyl ether; 5-Androstene-3β,16α,17β-triol, tris(trimethylsilyl) ether; 3β,16α,17β-Tris(trimethylsilyloxy)-5-androstene; TMS-protected Androst-5-ene triol
EINECS	Contact for details

Quality Control

Our 3β,16α,17β-Tris(Trimethylsilyloxy)Androst-5-Ene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our commitment to quality ensures reliable performance for your most demanding synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.