Description

4β-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Ethyl Ester is a specialized nitrosourea derivative with significant potential in advanced organic synthesis and pharmaceutical research. This compound matters for its role as a key intermediate in the development of novel therapeutic agents, particularly in oncology research where nitrosourea structures are of high interest. It is primarily needed by research scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical industries for developing new drug candidates and exploring complex chemical transformations.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel anticancer agents and other biologically active molecules.
• Oncology Research: Used in academic and industrial laboratories to study structure-activity relationships (SAR) of nitrosourea-based compounds.
• Medicinal Chemistry: Employed in the design and development of targeted therapies, leveraging its alkylating properties.
• Process Development: Acts as a key starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology: Utilized in probe development to study enzyme inhibition and cellular pathways.
• Fine Chemical Synthesis: Applied in custom synthesis projects requiring complex, high-purity nitrosourea derivatives.

Basic Information

Product Name	4β-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Ethyl Ester
CAS No.	33073-60-8
Molecular Formula	C12H20ClN3O4
Molecular Weight	305.76 g/mol
Synonyms	Ethyl 4β-[3-(2-chloroethyl)-3-nitrosoureido]-1α-cyclohexanecarboxylate; 1α-Cyclohexanecarboxylic acid, 4β-[3-(2-chloroethyl)-3-nitrosoureido]-, ethyl ester; NSC 172112; Nitrosourea CCNU derivative; 1-(2-Chloroethyl)-3-(4β-ethoxycarbonyl-1α-cyclohexyl)-1-nitrosourea; Lomustine analog intermediate
EINECS	Contact for details

Quality Control

Our 4β-[3-(2-Chloroethyl)-3-Nitrosoureido]-1α-Cyclohexanecarboxylic Acid Ethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature, the container should be opaque or kept in dark conditions. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.