Description

17β-[Bis(2-Chloroethyl)Amino]Androst-4-En-3-One is a nitrogen mustard derivative of androstenedione, representing a specialized class of steroidal alkylating agents. This compound is of significant interest in advanced pharmaceutical research, particularly for its potential as a targeted cytotoxin in oncology drug discovery. It serves as a critical synthetic intermediate and a key reference standard for researchers and manufacturers developing novel anti-cancer therapies and hormone-targeting agents. The precise chemical structure enables the study of structure-activity relationships (SAR) for steroidal compounds with alkylating properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational steroidal anti-cancer agents and targeted therapies.
• Oncology Research: Used as a reference standard and active compound in preclinical studies exploring the efficacy of nitrogen mustard conjugates.
• Biochemical Tool Compound: Employed in mechanistic studies to understand alkylation processes on specific biological targets within hormonal pathways.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemists to design and optimize new chemical entities (NCEs) with potential cytotoxic activity.
• Academic Research: Utilized in university and institutional laboratories for advanced studies in steroid chemistry and medicinal chemistry.
• Reference Material: Provides a high-purity standard for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	17β-[Bis(2-Chloroethyl)Amino]Androst-4-En-3-One
CAS No.	33068-77-8
Molecular Formula	C23H35Cl2NO
Molecular Weight	412.44 g/mol
Synonyms	17β-[Bis(2-chloroethyl)amino]androst-4-en-3-one; 17β-[Bis(2-chloroethyl)amino]-4-androsten-3-one; Androst-4-ene-3-one, 17-[bis(2-chloroethyl)amino]-; 17β-(N,N-Bis(2-chloroethyl)amino)androst-4-en-3-one; Steroidal nitrogen mustard; Estramustine analog
EINECS	Contact for details

Quality Control

Our 17β-[Bis(2-Chloroethyl)Amino]Androst-4-En-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing all critical quality attributes to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.