Description

9-Trimethylsilyl-9H-Purine is a key organosilicon-protected purine derivative, serving as a versatile synthetic intermediate in advanced organic chemistry. Its primary value lies in its role as a protecting group for the N-9 position of the purine ring system, enabling selective functionalization and the synthesis of complex nucleoside analogs. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and life science sectors engaged in developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of modified nucleosides and nucleotides used in antiviral and anticancer drug discovery programs.
• Agrochemical Research: Used in creating novel plant growth regulators and pesticide candidates based on purine chemistry.
• Nucleic Acid Chemistry: Serves as a protected building block for oligonucleotide synthesis and the preparation of labeled probes for diagnostics.
• Bioconjugation & Probe Development: Facilitates the site-specific modification of biomolecules for imaging, targeting, and diagnostic applications.
• Academic & Process R&D: A valuable reagent for methodology development in synthetic organic chemistry and scale-up process optimization.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals requiring regioselective protection and deprotection strategies.

Basic Information

Product Name	9-Trimethylsilyl-9H-Purine
CAS No.	32865-85-3
Molecular Formula	C8H12N4Si
Molecular Weight	192.30 g/mol
Synonyms	9H-Purine, 9-(trimethylsilyl)-; 9-(Trimethylsilyl)purine; N-Trimethylsilylpurine; Purine, 9-trimethylsilyl-; TMS-Purine; 9-TMS-Purine; 9-Trimethylsilylpurine; NSC 163063
EINECS	Contact for details

Quality Control

Our 9-Trimethylsilyl-9H-Purine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.