Description

9H-Purin-6-Amine, n-Methyl-9-(Trimethylsilyl)- is a high-purity, organosilicon-modified purine derivative, identified by CAS NO 32865-83-1. This compound is a critical advanced pharmaceutical intermediate and a versatile building block for nucleoside chemistry. It is primarily required by research institutions and fine chemical manufacturers engaged in the synthesis of novel antiviral agents, anticancer drugs, and modified oligonucleotides.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel nucleoside analogs and antiviral/anticancer prodrugs.
• Oligonucleotide Synthesis: Serves as a protected nucleobase monomer for the solid-phase synthesis of modified DNA/RNA strands.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new therapeutic agents targeting purine receptors.
• Bioconjugation: The trimethylsilyl group offers a handle for further functionalization and conjugation in bioconjugate and probe development.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in universities and R&D labs for exploring new synthetic methodologies in heterocyclic and organosilicon chemistry.

Basic Information

Item	Detail
Product Name	9H-Purin-6-Amine, n-Methyl-9-(Trimethylsilyl)-
CAS No.	32865-83-1
Molecular Formula	C9H15N5Si
Molecular Weight	221.34 g/mol
Synonyms	N-Methyl-9-(trimethylsilyl)adenine; 6-Amino-9-(trimethylsilyl)-N-methylpurine; 9-(Trimethylsilyl)-N-methyladenine; N-Methyl-9-trimethylsilyladenine; 9-(Trimethylsilyl)-N-methyl-9H-purin-6-amine; Adenine, N-methyl-9-(trimethylsilyl)-; 32865-83-1; TMS-Methyladenine
EINECS	Contact for details

Quality Control

Our production of 9H-Purin-6-Amine, n-Methyl-9-(Trimethylsilyl)- adheres to stringent in-process controls to ensure batch-to-batch consistency and high purity. Quality is verified through advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.