Description

tert-Butyl 2-Isocyano-3-Methylbutyrate is a versatile isocyanide building block used in multicomponent reactions and peptide synthesis. Its value lies in enabling the efficient, one-pot construction of complex heterocycles and peptidomimetics, which are crucial for pharmaceutical and agrochemical research. This high-purity intermediate is essential for R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries seeking to accelerate drug discovery and optimize synthetic routes.

Application

• Pharmaceutical Intermediate: A key reagent in the Ugi and Passerini multicomponent reactions for the rapid synthesis of diverse compound libraries for drug discovery.
• Peptidomimetic Synthesis: Used to introduce the isocyanide functional group for constructing non-natural peptide backbones and protease inhibitors.
• Agrochemical Research: Serves as a building block for creating novel heterocyclic compounds with potential herbicidal or insecticidal activity.
• Material Science: Employed in the development of functional polymers and smart materials via isocyanide-based polymerization techniques.
• Catalyst Ligand Precursor: Utilized in the synthesis of specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Facilitates the creation of activity-based probes and bioconjugation reagents for studying biological systems.

Basic Information

Product Name	tert-Butyl 2-Isocyano-3-Methylbutyrate
CAS No.	32755-42-3
Molecular Formula	C10H17NO2
Molecular Weight	183.25 g/mol
Synonyms	2-Isocyano-3-methylbutyric acid tert-butyl ester; tert-Butyl 2-isocyano-3-methylbutanoate; 3-Methyl-2-isocyanobutyric acid tert-butyl ester; Butanoic acid, 2-isocyano-3-methyl-, 1,1-dimethylethyl ester; Isocyanide C1; Ugi's Reagent derivative; (tert-Butoxycarbonyl)valine isocyanide; Boc-Val-NC
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Isocyano-3-Methylbutyrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.