Description

N,2'-o-Bis(Trimethylsilyl)Adenosine 3',5'-Phosphoric Acid Trimethylsilyl Ester is a key protected nucleoside derivative, specifically designed for advanced organic synthesis and pharmaceutical research. This compound is essential for the controlled synthesis of nucleotide analogs, offering superior stability and reactivity for complex molecular construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, biotechnology, and agrochemical industries for the development of novel active ingredients and diagnostic probes.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antiviral and anticancer nucleotide analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified RNA and DNA sequences for research and therapeutic applications.
• Prodrug Development: Serves as a protected precursor for creating prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog to investigate nucleotide-processing pathways.
• Agrochemical Research: Utilized in the development of novel plant growth regulators and pesticides based on nucleotide chemistry.
• Diagnostic Probe Synthesis: Acts as a starting material for creating labeled nucleotides used in imaging and diagnostic assays.

Basic Information

Item	Details
Product Name	N,2'-o-Bis(Trimethylsilyl)Adenosine 3',5'-Phosphoric Acid Trimethylsilyl Ester
CAS No.	32645-64-0
Molecular Formula	C22H43N5O7PSi3
Molecular Weight	623.90 g/mol
Synonyms	Adenosine, N,2'-O-bis(trimethylsilyl)-, 3',5'-(hydrogen phosphate) trimethylsilyl ester; 3',5'-O-(Trimethylsilyl)phosphoryl-N,2'-O-bis(trimethylsilyl)adenosine; Protected Adenosine Phosphotriester; TMS-Adenosine Phosphotriester; Silylated Adenosine Derivative; Nucleoside Phosphotriester Intermediate
EINECS	Contact for details

Quality Control

Every batch of N,2'-o-Bis(Trimethylsilyl)Adenosine 3',5'-Phosphoric Acid Trimethylsilyl Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided with each shipment to guarantee batch-to-batch consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions, preferably in a glovebox or under an inert atmosphere (argon/nitrogen) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.