Description

1-(Trimethylsilyl)-3-[(Trimethylsilyl)Amino]-2-Piperidone is a specialized organosilicon-protected piperidone derivative, a key building block in advanced organic synthesis. Its value lies in its dual silyl protection, which offers enhanced stability and controlled reactivity for constructing complex nitrogen-containing heterocycles. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Advanced Organic Synthesis: Serves as a versatile building block for constructing sophisticated nitrogen heterocycles through ring-opening, cross-coupling, or further functionalization reactions.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the piperidone scaffold is a key structural motif.
• Material Science: Potential monomer or modifier in the synthesis of specialty polymers and silicon-containing hybrid materials.
• Process Chemistry Development: Enables scalable synthetic routes due to the protective groups' stability under various reaction conditions.
• Academic & R&D Laboratories: A valuable reagent for methodological studies in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-(Trimethylsilyl)-3-[(Trimethylsilyl)Amino]-2-Piperidone
CAS No.	32565-12-1
Molecular Formula	C11H26N2OSi2
Molecular Weight	246.51 g/mol
Synonyms	3-[(Trimethylsilyl)amino]-1-(trimethylsilyl)-2-piperidone; 1-(Trimethylsilyl)-3-[(trimethylsilyl)amino]piperidin-2-one; 2-Piperidone, 1-(trimethylsilyl)-3-[(trimethylsilyl)amino]-; N-(Trimethylsilyl)-3-[(trimethylsilyl)amino]-2-piperidone; TMS-protected 3-amino-2-piperidone; Bis(trimethylsilyl) protected 3-amino-2-piperidone
EINECS	Contact for details

Quality Control

Our production of 1-(Trimethylsilyl)-3-[(Trimethylsilyl)Amino]-2-Piperidone adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.