Description

Rac-Febrifugine Dihydrochloride is a high-purity chemical compound of significant interest in pharmaceutical research and development. This material serves as a critical intermediate and reference standard for the synthesis and study of antimalarial agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in drug discovery and analytical method development. Consistent quality and reliable supply are paramount for ensuring reproducible experimental and production outcomes.

Application

• Pharmaceutical Intermediate: Key building block in the synthetic pathways for novel antimalarial compounds and related alkaloids.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: Employed in in-vitro and in-vivo studies to investigate mechanisms of action against Plasmodium species.
• Process Chemistry: Serves as a starting material or intermediate in scale-up and process optimization for active pharmaceutical ingredient (API) manufacturing.
• Academic Research: Utilized in university and institutional labs for medicinal chemistry projects and pharmacological studies.

Basic Information

Product Name	Rac-Febrifugine Dihydrochloride
CAS No.	32434-42-7
Molecular Formula	C16H21Cl2N3O3
Molecular Weight	374.26 g/mol
Synonyms	(±)-Febrifugine Dihydrochloride; DL-Febrifugine Dihydrochloride; Racemic Febrifugine Dihydrochloride; 3-[(2S,3R,4R)-3-Hydroxy-4-piperidinyl]-2(3H)-quinazolinone Dihydrochloride (racemic); Isofebrifugine Dihydrochloride (racemic); Dichroine B Dihydrochloride (racemic); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Rac-Febrifugine Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.