Description

Tetrahydro-2-Hydroxy-4-(Phosphonomethyl)-2H-1,4,2-Oxazaphosphorine 2-Oxide is a high-purity, specialized organophosphorus compound of significant interest in advanced chemical synthesis. This product matters for its role as a key intermediate or precursor in the development of novel pharmaceuticals and biologically active molecules, particularly those targeting specific enzymatic pathways. Industrial and research chemists in the pharmaceutical, agrochemical, and fine chemical sectors need this compound for its unique heterocyclic structure containing both phosphorus and nitrogen functionalities.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, especially those with phosphonate or phosphoramidate moieties for antiviral or anticancer activity.
• Agrochemical Research: Used in the development of new generation herbicides, insecticides, or plant growth regulators that leverage its phosphorus-based chemistry.
• Ligand Synthesis: Acts as a precursor for creating complexing agents or catalysts used in asymmetric synthesis and metal coordination chemistry.
• Bioconjugation Chemistry: Potential use in modifying biomolecules (e.g., peptides, nucleotides) due to its reactive functional groups.
• Material Science Precursor: Can be utilized in the synthesis of flame-retardant additives or specialty polymers with tailored properties.
• Chemical Biology Probes: Employed in research to develop enzyme inhibitors or activity-based probes for studying biochemical pathways.

Basic Information

Product Name	Tetrahydro-2-Hydroxy-4-(Phosphonomethyl)-2H-1,4,2-Oxazaphosphorine 2-Oxide
CAS No.	32422-02-9
Molecular Formula	C4H10NO6P
Molecular Weight	199.10 g/mol
Synonyms	2-Hydroxy-4-(phosphonomethyl)-tetrahydro-2H-1,4,2-oxazaphosphorine 2-oxide; 1,4,2-Oxazaphosphorinane, tetrahydro-2-hydroxy-4-(phosphonomethyl)-, 2-oxide; 4-(Phosphonomethyl)-2-hydroxy-tetrahydro-2H-1,4,2-oxazaphosphorine 2-oxide; Fosfomycin intermediate derivative; Phosphonic acid, P-[(2-hydroxy-2-oxido-1,4,2-oxazaphosphorinan-4-yl)methyl]-; Oxazaphosphorine phosphonate
EINECS	Contact for details

Quality Control

Our Tetrahydro-2-Hydroxy-4-(Phosphonomethyl)-2H-1,4,2-Oxazaphosphorine 2-Oxide is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.