Description

2-O,3-O,4-o-Trimethyl-1-O,6-o-Bis(Trimethylsilyl)-D-Glucopyranose CAS NO 32388-38-8 is a key protected sugar derivative, specifically a trimethylsilyl (TMS) ether of a partially methylated glucose. This compound is a crucial advanced synthetic intermediate in organic and medicinal chemistry, prized for its role in constructing complex carbohydrate structures and nucleoside analogs. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the production of novel therapeutics and bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of nucleoside analogs, antiviral agents, and other carbohydrate-based active pharmaceutical ingredients (APIs).
• Glycochemistry Research: Used in the study and synthesis of complex oligosaccharides, glycoconjugates, and glycomimetics for drug discovery.
• Protecting Group Strategy: The TMS and methyl groups serve as orthogonal protecting groups, enabling selective deprotection and further functionalization in multi-step syntheses.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, chiral auxiliaries, and ligands for asymmetric catalysis.
• Bioconjugation Chemistry: Acts as a precursor for linkers and spacers used in bioconjugation techniques for antibody-drug conjugates (ADCs) or diagnostic probes.
• Academic & Industrial R&D: Serves as a valuable reagent for method development and exploring new synthetic pathways in carbohydrate chemistry.

Basic Information

Product Name	2-O,3-O,4-o-Trimethyl-1-O,6-o-Bis(Trimethylsilyl)-D-Glucopyranose
CAS No.	32388-38-8
Molecular Formula	C15H34O6Si2
Molecular Weight	366.60 g/mol
Synonyms	1,6-Bis-O-(trimethylsilyl)-2,3,4-tri-O-methyl-D-glucopyranose; D-Glucopyranose, 1,6-bis-O-(trimethylsilyl)-2,3,4-tri-O-methyl-; 2,3,4-Tri-O-methyl-1,6-bis-O-(trimethylsilyl)-D-glucopyranose; 1,6-Di-O-trimethylsilyl-2,3,4-tri-O-methyl-D-glucopyranose; TMS-protected trimethyl glucose derivative; Protected D-glucose derivative
EINECS	Contact for details

Quality Control

Our production of 2-O,3-O,4-o-Trimethyl-1-O,6-o-Bis(Trimethylsilyl)-D-Glucopyranose adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.