Description

1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Threitol is a high-purity, fully protected derivative of D-threitol, a valuable chiral building block. This compound is essential for advanced organic synthesis, particularly in the pharmaceutical and fine chemical industries, where it serves as a key intermediate for constructing complex, stereochemically defined molecules. Its primary value lies in providing a robust, silyl-protected scaffold that enables selective deprotection and further functionalization under controlled conditions. Target users include R&D chemists and process development scientists working on nucleoside analogs, antiviral agents, and other chiral pharmaceuticals.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of nucleoside analogs, antiviral drugs (e.g., protease inhibitors), and other active pharmaceutical ingredients (APIs) requiring precise stereochemistry.
• Asymmetric Synthesis: Used as a chiral auxiliary or ligand precursor in catalytic asymmetric reactions to induce high enantioselectivity.
• Polymer Chemistry: Serves as a monomer or cross-linking agent for creating specialty polymers with specific optical or mechanical properties.
• Protecting Group Strategy: The tetrakis(trimethylsilyl) protection allows for sequential, orthogonal deprotection, enabling complex multi-step synthetic routes.
• Analytical Standard: Employed as a reference standard in chromatographic methods (HPLC, GC) for quality control of related compounds and metabolic studies.
• Material Science Research: Investigated for use in liquid crystals and advanced organic materials due to its defined molecular geometry.

Basic Information

Product Name	1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Threitol
CAS No.	32381-52-5
Molecular Formula	C16H42O4Si4
Molecular Weight	422.86 g/mol
Synonyms	D-Threitol, 1,2,3,4-tetrakis-O-(trimethylsilyl)-; Tetrakis(trimethylsilyl) D-threitol; 1,2,3,4-Tetrakis-O-(trimethylsilyl)-D-threitol; D-Threitol tetrakis(trimethylsilyl) ether; D-Threitol, tetrakis(trimethylsilyl) derivative; (2R,3R)-1,2,3,4-Tetrakis(trimethylsilyloxy)butane; TMS-D-Threitol
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-o-Tetrakis(Trimethylsilyl)-D-Threitol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and chiral integrity, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions (e.g., nitrogen or argon atmosphere) to prevent decomposition. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.