Description

Pregn-4-Ene-3,20-Dione, 11,17,21-Tris[(Trimethylsilyl)Oxy]-, Bis(o-Methyloxime), (11Beta)- is a high-purity, derivatized steroid compound, primarily utilized as a critical analytical reference standard and synthetic intermediate. Its value lies in enabling precise quantification and structural analysis of related corticosteroids in pharmaceutical research and quality control laboratories. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors who require reliable standards for method development, validation, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the identification and assay of corticosteroid APIs and related substances via HPLC, GC-MS, or LC-MS methods.
• Analytical Chemistry: Used in the development and validation of analytical methods for steroid analysis in complex matrices, including biological fluids and environmental samples.
• Metabolite Research: Acts as a derivatized analog in studies investigating the metabolism, pharmacokinetics, and bio-transformation pathways of synthetic corticosteroids.
• Impurity Characterization: Employed to identify, quantify, and qualify potential process-related impurities or degradation products in steroid-based drug substances.
• Synthetic Intermediate: The trimethylsilyl (TMS) and oxime protecting groups make it a valuable precursor in the multi-step organic synthesis of more complex steroid molecules.
• Quality Control & Assurance: Critical for in-house QC laboratories to ensure batch-to-batch consistency and compliance with pharmacopeial monographs for corticosteroid drugs.

Basic Information

Product Name	Pregn-4-Ene-3,20-Dione, 11,17,21-Tris[(Trimethylsilyl)Oxy]-, Bis(o-Methyloxime), (11Beta)-
CAS No.	32221-26-4
Molecular Formula	C33H62N2O6Si3
Molecular Weight	659.13 g/mol
Synonyms	11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 11,17,21-tris(trimethylsilyl) ether bis(O-methyloxime); Cortisol Tris(trimethylsilyl) Ether Bis(O-methyloxime); Hydrocortisone Tris-TMS Ether Bis(Methyloxime); 11β-Hydroxycorticosterone Tris(trimethylsilyl) Derivative; TMS Derivative of Cortisol Bis(O-Methyloxime); (11β)-11,17,21-Tris(trimethylsiloxy)pregn-4-ene-3,20-dione dioxime methyl ether
EINECS	Contact for details

Quality Control

Every batch of Pregn-4-Ene-3,20-Dione, 11,17,21-Tris[(Trimethylsilyl)Oxy]-, Bis(o-Methyloxime), (11Beta)- is manufactured and analyzed under strict quality management systems. Our products undergo rigorous identity, purity, and strength testing using advanced techniques like HPLC, GC-MS, and NMR to ensure they meet the exacting standards required for analytical and research purposes. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and chromatographic data is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 103.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.