Description

11,21-Bis[(Trimethylsilyl)Oxy]Pregn-4-Ene-3,20-Dione Bis(o-Methyloxime) is a high-purity, protected steroid derivative used as a critical synthetic intermediate. This compound is essential for researchers and manufacturers developing advanced pharmaceutical compounds, particularly in the steroid and hormone therapy fields. Its primary value lies in enabling precise chemical transformations while protecting sensitive functional groups during multi-step synthesis. Target users include pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on organic and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Research Chemical: Used in academic and industrial R&D for studying steroid metabolism, receptor binding, and developing novel therapeutic agents.
• Process Development: Serves as a protected precursor in scaling up synthetic routes for corticosteroid and progestogen analogs under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related steroid compounds.
• Biochemical Probe: Utilized in biochemical assays to investigate enzyme inhibition or modulation related to steroidogenic pathways.

Basic Information

Product Name	11,21-Bis[(Trimethylsilyl)Oxy]Pregn-4-Ene-3,20-Dione Bis(o-Methyloxime)
CAS No.	32206-60-3
Molecular Formula	C30H52N2O4Si2
Molecular Weight	560.92 g/mol
Synonyms	11β,21-Bis(trimethylsilyloxy)pregn-4-ene-3,20-dione dioxime; 11β,21-Bis-O-(trimethylsilyl)-17α-hydroxyprogesterone dioxime; Pregn-4-ene-3,20-dione, 11,21-bis[(trimethylsilyl)oxy]-, dioxime; 11,21-Di-O-trimethylsilyl-17α-hydroxyprogesterone dioxime; 32206-60-3; Protected 17α-Hydroxyprogesterone Derivative; TMS-protected steroid dioxime.
EINECS	Contact for details

Quality Control

Our 11,21-Bis[(Trimethylsilyl)Oxy]Pregn-4-Ene-3,20-Dione Bis(o-Methyloxime) is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal specifications and regulatory requirements for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.