Description

1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-β-L-arabinopyranose is a fully silylated derivative of the monosaccharide L-arabinose, designed for advanced synthetic applications. This compound matters as a crucial protected intermediate, offering enhanced solubility in organic solvents and stability for complex glycosylation and oligosaccharide synthesis. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the production of nucleoside analogs, carbohydrate-based drugs, and complex glycoconjugates.

Application

• Pharmaceutical Intermediate: A key protected building block for the synthesis of novel nucleoside antiviral or anticancer agents.
• Glycochemistry Research: Used in the study and construction of complex oligosaccharides and glycoconjugates due to its stable silyl protecting groups.
• Carbohydrate Chemistry: Serves as a versatile starting material for the preparation of selectively modified L-arabinose derivatives.
• Process Development: Employed in scale-up and optimization of synthetic routes for carbohydrate-based active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Can be utilized to create labeled sugar analogs for metabolic pathway studies and diagnostic applications.

Basic Information

Product Name	1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-β-L-Arabinopyranose
CAS No.	32166-73-7
Molecular Formula	C17H42O5Si4
Molecular Weight	450.86 g/mol
Synonyms	β-L-Arabinopyranose, 1,2,3,4-tetrakis-O-(trimethylsilyl)-; Tetrakis-O-trimethylsilyl-β-L-arabinopyranose; 1,2,3,4-Tetra-O-trimethylsilyl-β-L-arabinopyranose; TMS-Arabinose; L-Arabinose tetrakis(trimethylsilyl) ether; Per-O-trimethylsilyl-β-L-arabinose; Ara(β)1-OTMS; Protected L-Arabinose derivative
EINECS	Contact for details

Quality Control

Our 1-O,2-O,3-O,4-o-Tetrakis(trimethylsilyl)-β-L-arabinopyranose is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (¹H and ¹³C), and GC analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.