Description

1β-[(Trimethylsilyl)Oxy]-4β-Methylcyclohexane is a specialized organosilicon compound featuring a protected hydroxyl group on a methylated cyclohexane backbone. This structure makes it a valuable synthetic intermediate and protecting group reagent in advanced organic synthesis, particularly for introducing sterically defined functionalities. It is primarily utilized by pharmaceutical and fine chemical research & development teams for the production of complex molecules, including active pharmaceutical ingredients (APIs) and novel materials.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of steroidal compounds and other complex drug candidates.
• Advanced Organic Synthesis: Serves as a protected alcohol synthon for introducing the 4β-methylcyclohexanol moiety into target molecules under controlled conditions.
• Asymmetric Catalysis Research: Used as a substrate or ligand precursor in the development of new chiral catalysts and reactions.
• Material Science Precursor: Potential starting material for synthesizing functionalized siloxanes or cyclohexane-based polymers with specific properties.
• Process Chemistry: Employed in route scouting and optimization for scalable manufacturing of high-value fine chemicals.

Basic Information

Product Name	1β-[(Trimethylsilyl)Oxy]-4β-Methylcyclohexane
CAS No.	32147-23-2
Molecular Formula	C10H22OSi
Molecular Weight	186.37 g/mol
Synonyms	4β-Methylcyclohexyloxytrimethylsilane; trans-4-Methylcyclohexyloxytrimethylsilane; 1-[(Trimethylsilyl)oxy]-4-methylcyclohexane; Trimethyl(4-methylcyclohexyloxy)silane; O-Trimethylsilyl-4-methylcyclohexanol; TMS ether of 4-methylcyclohexanol; 4-Methylcyclohexanol trimethylsilyl ether
EINECS	Contact for details

Quality Control

Our 1β-[(Trimethylsilyl)Oxy]-4β-Methylcyclohexane is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.