Description

Boc-Glycine Methyl Ester CAS NO 31954-27-5 is a protected amino acid derivative, specifically the methyl ester of N-(tert-butoxycarbonyl)glycine, serving as a crucial building block in organic synthesis. Its primary value lies in providing a reactive carboxyl group and an amine group protected by the acid-labile Boc group, enabling controlled, sequential peptide bond formation. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries who require high-purity intermediates for developing active pharmaceutical ingredients (APIs) and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental starting material for the automated synthesis of peptides, where the Boc protecting group strategy is employed.
• Solution-Phase Peptide Synthesis: Used in the classical, stepwise construction of peptides in solution, particularly for shorter sequences or specialized modifications.
• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of various peptide-based drugs and therapeutic agents.
• Bioconjugation & Linker Chemistry: Utilized to introduce glycine spacers or to functionalize molecules with protected amine handles for further chemical modification.
• Research & Development: Critical for academic and industrial R&D in medicinal chemistry, biochemistry, and chemical biology for exploring new bioactive compounds.
• Custom Peptide Production: A standard reagent for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering custom peptide manufacturing services.

Basic Information

Item	Details
Product Name	Boc-Glycine Methyl Ester
CAS No.	31954-27-5
Molecular Formula	C8H15NO4
Molecular Weight	189.21 g/mol
Synonyms	N-(tert-Butoxycarbonyl)glycine methyl ester; Glycine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester; Boc-Gly-OMe; Methyl N-Boc-glycinate; N-Boc-glycine methyl ester; (tert-Butoxycarbonyl)glycine methyl ester; Boc-Glycine O-methyl ester; Methyl 2-[(tert-butoxycarbonyl)amino]acetate
EINECS	Contact for details

Quality Control

Our Boc-Glycine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and consistency for our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Melting Point	86 - 90 °C
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.