Description

N5-[(2,4-Dimethoxyphenyl)Methyl]-N2-[(Benzyloxy)Carbonyl]-L-Glutamine 4-Nitrophenyl Ester is a sophisticated, protected glutamine derivative designed as a key synthetic intermediate for peptide coupling and solid-phase synthesis. This compound matters because it offers a reactive ester group for efficient amide bond formation while its orthogonal protecting groups provide precise control in complex, multi-step organic syntheses. It is primarily needed by research chemists and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for constructing peptides and peptidomimetics with high fidelity.

Application

• Peptide Synthesis Intermediate: Serves as a crucial building block in the solid-phase and solution-phase synthesis of complex peptides and proteins.
• Pharmaceutical Research & Development: Used in the discovery and development of novel therapeutic peptides, prodrugs, and bioactive compounds.
• Bioconjugation Chemistry: Facilitates the site-specific labeling and modification of biomolecules for diagnostic and research applications.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes and tools for studying enzyme function and protein-protein interactions.
• Custom Oligomer Production: Essential for the controlled assembly of specialized oligomers and sequence-defined polymers in advanced materials science.
• Academic & Industrial Research: A valuable reagent for methodology development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	N5-[(2,4-Dimethoxyphenyl)Methyl]-N2-[(Benzyloxy)Carbonyl]-L-Glutamine 4-Nitrophenyl Ester
CAS No.	31874-53-0
Molecular Formula	C28H29N3O9
Molecular Weight	551.55 g/mol
Synonyms	Z-Gln(Dmp)-ONp; Cbz-Gln(Dmp)-ONp; N2-Carbobenzoxy-N5-(2,4-dimethoxybenzyl)-L-glutamine 4-nitrophenyl ester; L-Glutamine, N5-[(2,4-dimethoxyphenyl)methyl]-N-[(phenylmethoxy)carbonyl]-, 4-nitrophenyl ester; Benzyl N-{N-[2,4-Dimethoxybenzyl]-L-glutaminyl}carbamate 4-Nitrophenyl Ester; Glutamine derivative (protected); Fmoc-Gln(Trt)-OH related active ester; Peptide coupling reagent.
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing all critical parameters are available upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool environment. This material is hygroscopic (moisture-sensitive); ensure containers are sealed under inert atmosphere or with desiccant after opening to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.