Description

2-Chloro-6-(4-Fluorophenyl)Nicotinonitrile is a versatile and high-value pharmaceutical intermediate with the CAS registry number 31776-83-7. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs) due to its functionalized pyridine core and halogen substituents. It is primarily sought by research and development teams and production chemists in the pharmaceutical and agrochemical industries for constructing novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides and fungicides, leveraging its halogenated aromatic structure.
• Chemical Synthesis: Serves as a precursor for further functionalization, such as Suzuki-Miyaura cross-coupling reactions, due to the reactive chlorine atom.
• Material Science: Potential monomer or additive in the research of specialty polymers and advanced organic materials.
• Contract Research Organizations (CROs): Utilized in custom synthesis and medicinal chemistry projects for client-specific molecule libraries.

Basic Information

Product Name	2-Chloro-6-(4-Fluorophenyl)Nicotinonitrile
CAS No.	31776-83-7
Molecular Formula	C12H6ClFN2
Molecular Weight	232.64 g/mol
Synonyms	2-Chloro-6-(4-fluorophenyl)nicotinonitrile; 2-Chloro-6-(p-fluorophenyl)-3-cyanopyridine; 3-Cyano-2-chloro-6-(4-fluorophenyl)pyridine; 2-Chloro-6-(4-fluorophenyl)-3-pyridinecarbonitrile; Nicotinonitrile, 2-chloro-6-(4-fluorophenyl)-; 31776-83-7; 6-(4-Fluorophenyl)-2-chloronicotinonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-6-(4-Fluorophenyl)Nicotinonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical-grade intermediates. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.