Description

Ethyl 6-(4-Fluorophenyl)-2-Methylpyridine-3-Carboxylate is a high-purity fluorinated pyridine derivative, a crucial advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated aromatic motifs into their target structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the fluorophenyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport molecules or fluorinated liquid crystals.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke chemicals for clients.
• Academic and R&D Laboratories: Used in medicinal chemistry programs and methodological studies to explore new C-H functionalization and cross-coupling reactions.

Basic Information

Item	Details
Product Name	Ethyl 6-(4-Fluorophenyl)-2-Methylpyridine-3-Carboxylate
CAS No.	31676-67-2
Molecular Formula	C15H14FNO2
Molecular Weight	259.28 g/mol
Synonyms	Ethyl 6-(4-fluorophenyl)-2-methylnicotinate; 3-Pyridinecarboxylic acid, 6-(4-fluorophenyl)-2-methyl-, ethyl ester; 2-Methyl-6-(4-fluorophenyl)nicotinic acid ethyl ester; Ethyl 2-methyl-6-(p-fluorophenyl)nicotinate; 6-(4-Fluorophenyl)-2-methylpyridine-3-carboxylic acid ethyl ester; Ethyl 6-(p-fluorophenyl)-2-methylnicotinate
EINECS	Contact for details

Quality Control

Every batch of Ethyl 6-(4-Fluorophenyl)-2-Methylpyridine-3-Carboxylate is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.