Description

Methyl n-Benzoyl-4-Hydroxyprolinate is a high-purity, protected amino acid derivative of significant synthetic utility. This compound serves as a crucial chiral building block and intermediate in advanced organic synthesis, enabling the controlled construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other peptide mimetics.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected hydroxyproline residue with a benzoyl group on the amine.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme-substrate interactions and designing molecular probes.
• Asymmetric Synthesis: Acts as a starting material or auxiliary in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Chemical Biology: Utilized for the synthesis of labeled or modified peptides for diagnostic and mechanistic studies.

Basic Information

Product Name	Methyl n-Benzoyl-4-Hydroxyprolinate
CAS No.	31560-20-0
Molecular Formula	C14H17NO5
Molecular Weight	279.29 g/mol
Synonyms	Methyl N-Benzoyl-4-hydroxy-L-prolinate; L-Proline, 4-hydroxy-, N-benzoyl-, methyl ester; Methyl N-Benzoyl-4-hydroxyprolinate; Methyl (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylate; N-Benzoyl-4-hydroxy-L-proline methyl ester; N-Benzoyl-trans-4-hydroxy-L-proline methyl ester; Methyl 1-benzoyl-4-hydroxy-L-prolinate; Methyl N-benzoyl-trans-4-hydroxy-L-prolinate
EINECS	Contact for details

Quality Control

Our Methyl n-Benzoyl-4-Hydroxyprolinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.