Description

Methyl 2-Chloro-2-(Triphenylphosphoranylidene)Acetate is a specialized Wittig-Horner reagent, a key building block in organic synthesis. Its primary value lies in its ability to facilitate the efficient formation of α-chloro-alpha,β-unsaturated esters, which are crucial intermediates for constructing complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where precise carbon-carbon bond formation is required.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for constructing α-chloro acrylate moieties found in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Production: Used in the synthesis of complex molecules for herbicides, fungicides, and insecticides, leveraging its ability to introduce functionalized alkene groups.
• Advanced Material Precursor: Serves as a building block for monomers and polymers with specific electronic or structural properties in material science research.
• Academic & Industrial R&D: A fundamental tool in method development and synthetic organic chemistry for creating novel carbon-carbon bonds under mild conditions.
• Fine Chemical Manufacturing: Employed in the multi-step synthesis of complex fragrance, flavor, and specialty chemical compounds.

Basic Information

Product Name	Methyl 2-Chloro-2-(Triphenylphosphoranylidene)Acetate
CAS No.	31459-98-0
Molecular Formula	C21H18ClO2P
Molecular Weight	368.79 g/mol
Synonyms	Methyl (chloro)(triphenylphosphoranylidene)acetate; Methyl 2-Chloro-2-(triphenyl-λ5-phosphanylidene)acetate; (Chloro)(triphenylphosphoranylidene)acetic acid methyl ester; Methyl α-chloro-α-(triphenylphosphoranylidene)acetate; Wittig-Horner reagent; Horner-Wadsworth-Emmons reagent (chloro variant); Triphenylphosphoranylidene chloroacetic acid methyl ester; Phosphonium, [(chloroacetyl)methylenyl]triphenyl-, inner salt
EINECS	Contact for details

Quality Control

Our production of Methyl 2-Chloro-2-(Triphenylphosphoranylidene)Acetate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including assay by NMR or HPLC, identification by FT-IR, and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to moisture and oxidation. Keep the container tightly sealed when not in use to prevent degradation from atmospheric humidity and oxygen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (NMR/HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.