Description

(1R,2S)-Rel-1,2-Cyclobutanedicarboxylic Acid, 1-Methyl Ester is a high-purity chiral building block of significant importance in advanced organic synthesis. This compound serves as a critical intermediate for constructing complex, stereochemically defined molecules, enabling the development of novel pharmaceuticals and fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of antiviral and anticancer drugs.
• Asymmetric Catalyst Ligand Precursor: Used in the preparation of chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Agrochemical Synthesis: Employed in the research and production of enantiomerically pure pesticides and herbicides for enhanced efficacy.
• Fine Chemical Building Block: Utilized in the multi-step synthesis of complex natural products and specialty chemicals requiring precise stereochemistry.
• Polymer Chemistry Research: Acts as a monomer or co-monomer for developing novel polymers with specific structural and chiral properties.
• Academic & Industrial R&D: Serves as a standard or reagent in method development and exploratory chemistry within laboratory settings.

Basic Information

Product Name	(1R,2S)-Rel-1,2-Cyclobutanedicarboxylic Acid, 1-Methyl Ester
CAS No.	31420-52-7
Molecular Formula	C8H12O4
Molecular Weight	172.18 g/mol
Synonyms	(1R,2S)-1,2-Cyclobutanedicarboxylic Acid 1-Methyl Ester; (1R,2S)-1-Methyl Cyclobutane-1,2-dicarboxylate; rel-(1R,2S)-Methyl Hydrogen Cyclobutane-1,2-dicarboxylate; (1R,2S)-Methyl Hydrogen 1,2-Cyclobutanedicarboxylate; (1R,2S)-Cyclobutane-1,2-dicarboxylic Acid Monomethyl Ester; Methyl (1R,2S)-1,2-Cyclobutanedicarboxylate; (1R,2S)-CBDA 1-ME
EINECS	Contact for details

Quality Control

Our (1R,2S)-Rel-1,2-Cyclobutanedicarboxylic Acid, 1-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity and chemical identity verification, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.