Description

2-Chloro-5-Fluoropyridine is a versatile halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the pyridine ring, enabling selective functionalization for creating complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Ligand and Catalyst Preparation: Used in the synthesis of specialized ligands for metal-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Material Science Research: Precursor for functionalized pyridine units in organic electronic materials and liquid crystals.
• Custom Synthesis and R&D: A versatile starting material for contract research organizations and discovery chemistry labs exploring new chemical entities.

Basic Information

Product Name	2-Chloro-5-Fluoropyridine
CAS No.	31301-51-6
Molecular Formula	C5H3ClFN
Molecular Weight	131.54 g/mol
Synonyms	5-Fluoro-2-chloropyridine; 2-Chloro-5-fluoropyridine; 5-Fluoropyridin-2-yl chloride; 2-Chloro-5-fluoro-pyridine; 31301-51-6; 5-Fluoro-2-chloro-pyridine; 2-Chloro-5-fluoro-azine; 2-Chloro-5-fluoropyridine (major)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoropyridine is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC and GC analysis, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports applications requiring GMP-grade intermediates and research-scale materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible materials. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.