Description

1-Oxoestazolam is a high-purity pharmaceutical intermediate and reference standard of significant importance in research and development. This compound is valued for its role in the synthesis and analytical characterization of related benzodiazepine derivatives. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in medicinal chemistry and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced benzodiazepine-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control testing in HPLC, GC-MS, and other chromatographic systems.
• Metabolite Studies: Employed in pharmacological and toxicological research to study the metabolic pathways of estazolam and related compounds.
• Forensic Analysis: Serves as a certified reference material for the identification and quantification of substances in forensic toxicology.
• Academic Research: Used in university and institutional labs for studies in neuropharmacology, organic synthesis, and drug design.
• Impurity Profiling: Critical for identifying and quantifying potential impurities and degradation products in pharmaceutical formulations.

Basic Information

Product Name	1-Oxoestazolam
CAS No.	31262-82-5
Molecular Formula	C₁₆H₁₁ClN₄O
Molecular Weight	310.74 g/mol
Synonyms	1-Oxoestazolam; 8-Chloro-6-phenyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-1-one; Estazolam Impurity C; Estazolam Related Compound C; 1-Oxo-Estazolam; 1-Oxo Estazolam; 1-Oxestazolam; 31262-82-5
EINECS	Contact for details

Quality Control

Our 1-Oxoestazolam is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC purity assay, residual solvent analysis, and identity confirmation (IR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packing.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.