Description

Methyl 2-Bromo-2-Cyano-Acetate is a versatile and highly reactive brominated cyanoacetate ester, serving as a critical building block in advanced organic synthesis. Its unique bifunctional structure, featuring both a bromine atom and a cyano group, makes it an invaluable reagent for constructing complex heterocycles and pharmaceutical intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce functional complexity into target molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing pyrimidine, pyridine, and other nitrogen-containing heterocycles.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity to create complex bioactive structures.
• Fine Chemical Building Block: Employed in multi-step organic synthesis for creating dyes, pigments, and advanced materials due to its electrophilic bromine and active methylene group.
• Cross-Coupling Reactions: Serves as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for carbon-carbon bond formation.
• Nucleophilic Substitution: The bromine atom is readily displaced by various nucleophiles (amines, thiols, alkoxides), enabling diverse functionalization.
• Chemical Research & Development: A valuable tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular libraries.

Basic Information

Product Name	Methyl 2-Bromo-2-Cyano-Acetate
CAS No.	31253-11-9
Molecular Formula	C5H6BrNO2
Molecular Weight	192.01 g/mol
Synonyms	Methyl Bromocyanoacetate; 2-Bromo-2-cyanoacetic acid methyl ester; Bromocyanoacetic Acid Methyl Ester; Methyl α-Bromo-α-cyanoacetate; Methyl (bromocyano)acetate; Acetic acid, 2-bromo-2-cyano-, methyl ester; NSC 163045
EINECS	Contact for details

Quality Control

Our Methyl 2-Bromo-2-Cyano-Acetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity, consistency, and reliability for your synthetic processes. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.